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48 Alternatively, membrane molecules such as GARP and LRRC33 which bind and present latent TGF- on the surface of one cell can cooperate with the V8 integrin expressed on a different cell to activate TGF- in trans

Mitophagy, in particular, serves as a key mechanism for maintaining metabolic homeostasis by selectively removing damaged mitochondria and limiting the accumulation of ROS [47].In CRC, the PINK1Parkin-mediated mitophagy pathway and Drp1-driven mitochondrial fission have been shown to act in concert to preserve mitochondrial quality under chemotherapeutic stress [48]

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JCO Precis Oncol 5:613-621, 2021

Alcohol may also worsen liver problems and increase the risk of stomach upset