treatment of hyperammonemia with l-carnitine reduces ammonia levels and alleviates covert encephalopathy: A randomized trial The treatment effect of l-carnitine

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33 Additionally, gut dysbiosis has been shown to predict poor outcomes in HE

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In parallel, studies using human iPSC-derived brain organoids reveal that esketamine induces rapid, concentration-dependent metabolic reprogramming, characterized by transient suppression of OXPHOS and glycolysis, accompanied by altered intracellular energy status, Ca signaling, and neuronal excitability [138]

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