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doi: 10.1038/nrclinonc.2015.117

Additionally, hypoxic environment in breast tumors brings about increased production of reactive oxygen species (ROS) (32), at the same time, induced hypoxia-inducible factor 1 (HIF-1) is able to boost glucose metabolism to maintain the redox homeostasis (33)

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These effects involve a link between neuroinflammatory processes and glutamate homeostasis