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Statistically, in healthy individuals, about 12 h after ED ingestion, there is an increase in systolic blood pressure by 610 mmHg, diastolic blood pressure by 36 mmHg, heart rate by about 37 beats/minute, and QT interval prolongation up to 2225 ms

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Additionally, we generated a CRISPR/Cas9 mutant mouse, ccOzz / , carrying a single base pair deletion that introduced a stop codon eight amino acids downstream of the start site (Fig

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