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Neuroimaging and histological studies have provided evidence of significant iron accumulation in affected regions in both patients and animal models, suggesting a role for ferroptosis in the distinctive pattern of motor neuron loss in ALS

This may be due to the highly reactive nature of H 2 O 2 and thus perhaps a triple fusion of PDI-GPx7-Ero1 may supply H 2 O 2 to GPx7 in close proximity

It should be noted that the management of JHR-associated fever in our cohort sometimes included the empirical use of indomethacin suppositories

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In fact, this discrepancy could be due to the measurement method

doi: 10.1165/AJRCMB.17.3.2998M 100 LiewFYLiYSevernAMillottSSchmidtJSalterMet al