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A history of airplane travel triggering symptoms might lead one to consider either perilymph fistula or MdDS, but classic perilymph fistula presents with a sudden popping noise in the ear and is soon followed by hearing loss, vertigo, and tinnitus.12 Again, MdDS could begin following a history of air travel but it would not present with hearing changes
Experimental models further demonstrate that PM2.5 disrupts BBB integrity and activates microglia [94, 95]

Aggregated and deposited -synuclein is directly associated with the disruption of cellular homeostasis and neuronal death (Jenner 2003)

Inorganic sulfur compounds include sulfides, sulfates, sulfites, and elemental sulfur

10.1016/j.cell.2017.09.021 Redox Biol