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It is important to use a model where NAC (at the doses used) has a clear inhibitory effect on ethanol intake, such that a possible association with neuroinflammation or oxidative stress can be investigated

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Several investigators have reported possible mechanisms of impairment of endothelial function in hypertension: increase in amount of the endogenous eNOS inhibitor asymmetrical dimethylarginine, increases in amounts of vasoconstrictors, such as Ang II, endothelin-1 and norepinephrine, and inactivation of NO by ROS

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Funding This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HH21C0004), and a National Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF-2020R1F1A1072720)

2013;9: e1003412