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TXNIP, in particular, achieves bidirectional autophagy regulation by engaging with distinct target proteins, such as the metabolic regulators mTOR and AMPK, the stress sensor REDD1, the master transcription factor TFEB, and by influencing the PI3K/Akt/mTOR signaling pathway

doi: 10.3390/nu13124188

Glutamate Modulation: NMDA receptor antagonists and mGluR2/3 agonists are being investigated to restore proper glutamate signaling, potentially alleviating both cognitive and affective symptoms

[DOI] [PubMed] [Google Scholar] 47.Kunca V., iliak M

Furthermore, citrate is an intermediate for sterol and fatty acid biosynthesis 614,615 and is used in astrocytes for the production of cholesterol, supporting synaptogenesis 616 , lipogenesis and lipid droplet formation in astrocytes 614,615