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Therefore, the ASD genetic models induced in mice should be established on an identified genetic cause of a disease, reflect key aspects of the human symptoms and respond to pharmacotherapies that are operational in the human diseases (Chadman et al., Genetic animal models of ASD A considerable advancement in detecting the genetic basis of several human diseases has been achieved by geneticists

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[DOI] [PMC free article] [PubMed] [Google Scholar] [293].Ho Kim S, Mo Chung J, An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat, Pain 50(3) (1992) 355363

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics

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