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The main difference is how and how often theyre taken.Similarities: Both are FDA-approved Wegovy formulations Both use semaglutide as the active ingredient Both follow a gradual dose-increase schedule determined by a provider Side effects are generally similar and can be managed with provider support Differences: Wegovy pen: Taken as a once-weekly injection Wegovy pill: Taken orally once per day Your Shed provider will help determine which option may be appropriate based on your health history, preferences, and treatment goals

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Wan-Sheng Chen, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

10.1073/pnas.0902675106 20 ChukyoA.ChibaT.KambeT.YamamotoK.KawakamiK.TaguchiK.et al

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