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With that said, some muscles (like the deltoid muscle of the upper arm) are smaller in some people, and it is possible to hit bone if the shot is not given in the thickest part

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Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity

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