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We monitor PubMed for new peer-reviewed studies on this topic and email a short summary when something meaningful changes.

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These includes: Stomach cramps Nausea Vomiting Diarrhea Some people might also complain of a fishy body odor, which is not generally harmful but might be bothersome

Dissociative anesthetics (ketamine and nitrous oxide) impair glutamatergic neurotransmission and mitochondrial function, contributing to excitotoxicity and neurodegeneration