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More recently, IL-6 has been identified as a decisive cytokine for the differentiation of CD4 + T cells into Th17 cells, which are currently considered as a major T-cell population endowed with pro-inflammatory activities 45

HMGB1, a potent proinflammatory cytokine in sepsis

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Furthermore, the extract exhibited a protective role by preserving crucial hepatic antioxidants in the body, such as superoxide dismutase (SOD) and glutathione (GSH), while concurrently inhibiting the activity of -glucuronidase, a marker associated with liver injury [2]