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A systematic review and meta-analysis used to inform international PCOS guidelines discusses potential benefits and limitations (Fitz et al., 2024) in PubMeds record for the review

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Unlike oral supplements that must be digested, B12 shots deliver the vitamin directly to the bloodstream, providing immediate energy

However, given the results reported in previous studies (2,25,31-33) that used moderate/high doses of vitamin B12, it should be possible to demonstrate the non-inferiority of the oral treatment with this power level

Continued monitoring and formal pharmacovigilance would be appropriate if AOD-9604 were pursued clinically, but such monitoring does not exist for supplement use