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Many people choose to take vitamin B12 earlier in the day and vitamin D with a meal, but timing can be adjusted based on personal preference and routine

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However, research shows that all forms of B12 follow the same route of absorption, including being bound to and released from the same transport and other proteins and so researchers believe that supplementing with adenosylcobalamin or methylcobalamin is unlikely to offer an advantage over cyanocobalamin in healthy people (Obeid et al., 2015)

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The most common causes of macrocytic anemia are deficiencies in vitamin B12 or folic acid, which can result from poor dietary intake, malabsorption, or other medical conditions