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Ketones, primarily synthesized in the liver, act as an alternative fuel source for neurons (Koppel et al

These proteins attach to pathogens after being activated by a recognition protein such as C-reactive protein (CRP), natural IgM, or mannan-binding lectin

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Meanwhile, single-cell RNA sequencing (scRNA-seq) has revealed that stem-like cell populations with elevated OXPHOS activity contribute to drug resistance and metastatic potential, providing direct evidence for the cellular basis of metabolic heterogeneity in CRC [166, 167]

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