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When you take a GLP-1 agonist, it stimulates these receptors in the same way the hormone does and produces the same effects: reduced appetite, lower blood sugar levels, and diminished cravings

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Source for the keratinocyte proliferation hypothesis and the comparison to glucocorticoid-induced skin atrophy

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Instead of targeting a single receptor, retatrutide activates three hormone receptors involved in appetite and metabolism: GLP-1 receptor GIP receptor Glucagon receptor Because it activates all three pathways, it is often called a triple agonist

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