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Dimethyloxalyl glycine (DMOG) was used as a control for broad-spectrum 2-OGDD inhibition

Naunyn Schmiedebergs Arch Pharmacol 396:877900

These findings suggest that kokumi substances are divided into at least two groups: one that exerts its effect via interactions with kokumi receptors, and another that directly binds with T1Rs and other G-protein-coupled receptors and exerts its effect by allosteric modulation of these receptors

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This rapid clearance contributes to the favorable safety profile, as the compound itself does not accumulate in tissues

In the National Health and Nutrition Examination Survey of U.S