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Bioavailability: NAC has an oral bioavailability of approximately 6-10% due to extensive first-pass metabolism, but the deacetylated cysteine that reaches tissues effectively drives glutathione synthesis [9]

These changes contribute to the aggressive and metastatic behaviors of HCC

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These RBC enzyme disorders are due to abnormalities in the HMP shunt and glutathione metabolism, glycolytic enzyme deficiencies, and abnormalities in purine and pyrimidine metabolism