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12 Hypoxia can reduce the production of free radicals or abnormal signaling substrates and activate the vHL-PHD-HIF hypoxic transcriptional program, which in turn activates glycolysis to generate ATP and reduces ROS production caused by impaired electron transfer in ETC, thereby rescuing the ETC-inhibited cellular phenotype

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The contribution of plant dioxygenases to hypoxia signaling

doi: 10.1038/s41419-023-06073-8 62 ZhangJLiuRGaoSLiWChenYMengYet al