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Stimulates collagen production, improving skin texture

The result is hydrated, glowing skin with improved radiance and a more even skin tone

These agents include agonists targeting costimulatory receptors such as CD137 (e.g., urelumab or anti-4-1BB/PD-L1 bispecific antibody) [347,348,349,350], CD20 (e.g., rituximab) [351, 352], CD27 (e.g., varlilumab, augments T-cell proliferation) [353, 354], OX40/OX40 ligand [355], CD80 [356], as well as agents like CD40 agonists (e.g., sotigalimab) that enhance antigen presentation by activating DCs and macrophages, which improves antigen presentation and primes a more robust T-cell response [357, 358]

doi: 10.3390/ijms26010321 6 CoppolaF.FerrariB.BarusiL.CaccavariV.SalvaraniM

(eds.) Krause Dietoterapia

The live tick can be disposed of by putting it in alcohol, putting it in a sealed bag or container, wrapping it in tape, or flushing it down the toilet