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However, basal levels of phase I and most phase II drug metabolizing enzymes in HepG2 cells are very low compared to human hepatocytes (Wilkening et al., 2003

The association between these diseases may be attributed to shared inflammatory pathways and abnormal immunomodulatory mechanisms

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68 Notch signaling, for example, preserves the undifferentiated state of NSCs by repressing proneural genes such as Mash1 and Neurogenin1, preventing premature differentiation
