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In fact, there was a 2022 case report presented a 22-year-old student who exhibited hyperpigmentation as the only symptom of B12 deficiency

10.1111/nyas.15187 22 GrantB.KeanJ.ValiN.CampbellJ.MadenL.BijralP.et al (2023b)

In the case of vitamin B12 deficiency, SAM cannot be formed
In tolerance assays forty-two hours after the conditioning regimen, shorter preconvulsive latencies than that in healthy mice following an isoniazid treatment (800 mg/kg i.p.) were observed if diazepam (5.0 mg/kg i.p.) was given again to mice previously conditioned with diazepam alone

However, further research and clinical trials are necessary to determine its suitability for human use [7]
There is limited evidence regarding the relationship between high vitamin B12 levels and blood sugar regulation
