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Acknowledgments We thank the drawing tools provided by Figdraw (www.figdraw.com)

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Li H, Gu B, Zhang Y, Lewis DF, Wang Y: Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta

This method utilizes genetic markers associated with the exposure as instrumental variables to provide causal estimates between exposures and disease outcomes while testing for the presence of pleiotropy (association of genetic variables with the outcome through more than one causative trail) [241]

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