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In animal-model work, NNMT inhibition with 5-Amino-1MQ has been associated with changes in adipose-tissue mass, in NAD+ pool sizes (because NNMT consumes nicotinamide that would otherwise feed the NAD+ salvage pathway), and in methyl-donor dynamics (because NNMT consumes S-adenosylmethionine)

10.1016/j.ejphar.2019.01.030 [DOI] [PubMed] [Google Scholar] Sikiric P., Hahm K

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Another cause - granted, identified as rare - is a B12 deficiency

Timeframe Considerations: The company notes that consistent use over several weeks is typical before users may notice changes, if any occur