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fbf-1 fbf-2 mutants (TumFBF) (Figure 2A, lanes 2 and 3)

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doi: 10.1126/science.1074240

Recent studies have reported that hyperandrogenemia induces disorders of glucose and lipid metabolism at the central and peripheral levels, promoting the development and progression of obesity and type 2 diabetes in both female individuals and rodents with PCOS (40, 41)

( D ) Knockdown of transcription factor gene skn-1 by RNAi extends the lifespan of SFP-1-overexpressing worms