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In summary, rational design has led to the development of two long-acting GLP-1 analogs, liraglutide and semaglutide, that have made a vast contribution to the management of T2D in terms of improvements in glycemic control, body weight, blood pressure, lipids, beta-cell function, and CV outcomes

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In models of depression induced by alcohol withdrawal, Yawalkar et al

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2010 May;68(5):1059-64