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Tetrahydrofolic acid, methyltetrahydrofolate, and other folic acid congeners are essential for the maintenance of normal erythropoiesis and are also required cofactors for the synthesis of purine and thymidylate nucleic acids

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This might be one of the best arguments as to why there needs to be more human trials

Once-daily dosing offers simplicity and better compliance, while split dosing theoretically maintains more stable tissue concentrations throughout the day

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