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As mentioned in the Introduction, there are many factors that contribute to ROS including oxygen and blue light that can penetrate the cornea and lens and induce photochemical damage 16,20

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doi: 10.1016/j.cyto.2022.156107 27 LiuXQShiMZBaiYTSuXLLiuYMWuJCet al

In vitro competitive binding assays have quantified the displacement characteristics of IGF-1 DES relative to full-length IGF-1 at IGFBP-1 through IGFBP-6

An in vitro study also has shown that riboflavin depletion in intestinal cells could lead to overproduction of ROS in these cells (Reference Lee, Corfe and Powers46)

For example, fucoxanthin was found to induce a G0/G1 phase block in cancer cells while upregulating GADD45, a DNA repair gene regulated by p53, which helps maintain genomic stability and reduce cancer risk (44)