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Am J Physiol (2008) 295:R188290.10.1152/ajpregu.90529.2008 29 KoppUCSmithLADibonaGF

Homocysteine-induced injury to the arterial wall is one of the factors that can initiate the process of atherosclerosis, leading to endothelial dysfunction and eventually to heart attacks and strokes (1)

Zelante T, Iannitti RG, Cunha C, et al

For instance, it was shown that sulfhydration of Cys38 in p65, which stimulates its transcriptional activity, predominated early after an H 2 S-forming TNF- treatment but that it declined with time being succeeded by a reciprocal enhancement of Cys38 nitrosylation which inhibited it (Sen et al., 2012)
findings remain investigational

This has also been confirmed in vitro
