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However, sometimes a chelator may expose the metal to the biological environment and thus increase the toxicity of the metal (Figure 3)

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A recent comprehensive in vivo study performed in fully awake mice provides evidence that astrocyte Ca 2+ does not initiate or mediate neurovascular coupling when neuronal activation is short ( 40 kDa) but not small ( 50%) seems to be required to induce BBB leakage (101)

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