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Functionally, impaired glucose tolerance (IGT), a key prediabetic state, is associated with reduced first- and second-phase insulin secretion and lower total insulin content normalised to beta cell mass [22]

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Homo-cysteine is condensed with serine by CBS, and the resulting cystathionine is hydrolyzed by CSE, giving rise to cysteine, ammonia, and -ketoglutarate (138)

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