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This effect is not attributable to with a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated glutamatergic signaling, but instead depends on voltage-gated activity [28], underscoring that RGC responses to altered synaptic input are regulated by both structural remodeling and intrinsic excitability

After incubation, the sample was centrifuged at 4000 rpm for 5 min and the supernatant was discarded

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These ROS further amplify the inflammatory response by regulating redox-sensitive transcription factors, including nuclear factor B (NF-B), activator protein-1 and c-Jun N-terminal kinase (JNK) (15)

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