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The most frequently described immunodeficiency was common variable immunodeficiency disorder (CVID, n=110/715, 15.4%), reported in most ICF syndrome type 1 (n=56/58, 97%) and Kabuki syndrome type 1 (n=40/197, 20%) (143, 145, 146, 153, 157, 159, 160), Rubinstein-Taybi syndrome type 1 (n=2/6, 25%) (116, 119) and type 2 (n=4/26, 15%) (126128), Wiedemann-Steiner syndrome (n=3/60, 5%) (60) and single cases of SETD1A-syndrome (n=1/16, 6%) (102), MRAD 32 syndrome (n=1/83, 1%) (133, 137), HSAIN1E/ADCA-DN syndrome (n=1/1, 100%) (137) and MRAD 51 syndrome (n=1/7, 14.3%) (89)

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