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Conflict of interests The authors declare that there is no conflict of interest in this paper

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Despite holding great promise, it is important to consider that high doses of butyrate may not be ideal, as demonstrated by Xu et al

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Interestingly, EcGGT poorly accepts D-amino acids, while Bacillus GGTs can accept both L- and D-isomers, thus showing relaxed stereoselectivity at the acceptor site (Ogawa et al., 1991

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10.3389/fnagi.2019.00021 209 NieK.GaoY.MeiM.GuoM.HuangZ.WangL.et al

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The phenotype of the proband was less severe than other IGF1 mutation patients with normal birth size (3.0kg) but significant post-natal growth impairment (presenting height -4.0 SD), normal hearing, normal development except for attention deficit hyperactivity disorder and mildly reduced serum concentrations of IGF-I (-2.2 SD) with normal IGFBP-3 serum levels (-1.25 SD)

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