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Conflict of interests The authors declare that there is no conflict of interest in this paper

Despite holding great promise, it is important to consider that high doses of butyrate may not be ideal, as demonstrated by Xu et al
Interestingly, EcGGT poorly accepts D-amino acids, while Bacillus GGTs can accept both L- and D-isomers, thus showing relaxed stereoselectivity at the acceptor site (Ogawa et al., 1991

10.3389/fnagi.2019.00021 209 NieK.GaoY.MeiM.GuoM.HuangZ.WangL.et al

Archived from the original on 11 May 2025

The phenotype of the proband was less severe than other IGF1 mutation patients with normal birth size (3.0kg) but significant post-natal growth impairment (presenting height -4.0 SD), normal hearing, normal development except for attention deficit hyperactivity disorder and mildly reduced serum concentrations of IGF-I (-2.2 SD) with normal IGFBP-3 serum levels (-1.25 SD)
