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386,387 After myocardial I/R injury, the activation of Wnt/-catenin signaling can promote YAP1 transcription, thereby inhibiting Hippo-YAP signaling and subsequently suppressing cell hypertrophy induced by myocardial I/R injury 142 (Fig

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Furthermore, the bone loss in mice induced by ovariectomy could be abrogated by ISA treatment, confirming its in vivo anti-osteoporotic effects