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Patients who develop symptoms of unexplained hyperammonemic encephalopathy while receiving valproate therapy should receive prompt treatment (including discontinuation of valproate therapy) and be evaluated for underlying urea cycle disorders (see Contraindications and Hyperammonemia and Encephalopathy Associated with Concomitant Topiramate Use as follows)

Pathway enrichment analyses indicated alterations in branched-chain amino acid metabolism and one-carbon metabolic pathways

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How to Use: Apply to lip liberally as needed