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These findings suggest that NNMT inhibition may modulate the metabolic responses to physical activity by altering cellular energy metabolism across multiple tissue types

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These FAHFAs can be stored as TAGs (156) and mobilized during cold exposure by PNPLA2 to promote de-novo lipogenesis and FA-esterification in an insulin-independent manner (157), possibly explaining the coupling of lipolysis to lipogenesis in adipocytes (151)

In animal experiments, STAT6 inhibition reduced the expression of claudin-2, protected the structure and function of the intestinal barrier, and alleviated the symptoms of UC