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Insufficient intrinsic factor production, common in older adults due to age-related absorption decline, can also lead to deficiency

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Avec lge, labsorption de la B12 diminue , ce qui justifie lutilisation de complments doses plus leves chez les plus de 50 ans, gnralement entre 500 et 1 000 microgrammes selon les recommandations de leur professionnel de sant

Symptoms often include fatigue, weakness, and neurological problems

A compound with genuinely novel mechanism data from multiple animal species, demonstrated efficacy, and a clear molecular target essentially disappeared from the clinical pipeline without public explanation