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All the evidence related to cuproplasia and cuproptosis is derived from retrospective studies, with only the association between reduced copper levels and a higher risk of lung cancer stemming from a meta-analysis of retrospective data

10.1038/nm.3624 [DOI] [PubMed] [Google Scholar] Winterbourn CC, Hampton MB

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In a parallel study similarly indicated that sorafenib upregulated MT1G expression in HCC cells

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Active B12 and Folate may be especially beneficial for persons who are vegetarian or with impaired gastrointestinal absorption due to aging, illness, surgery or a methylation deficiency