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and (b) a catalytically active closed conformation, where the Mg 2+ -isocitrate complex is able to bind between the large and small domains of the enzyme, consequent to relief of the steric impediment by Asp279 to the Mg 2+ -isocitrate complex binding

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This indicated that HO-1 exhibits excellent benefits in ferroptosis of DN since it is an important downstream target affected by HGBM1

[2] Their findings were reassuring: pulsatile GH secretion persisted even during sustained CJC-1295 stimulation
