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Description
It inhibits the NLRP3 inflammasome in renal macrophages by enhancing AMPK-mediated autophagy, thereby reducing caspase-1 activation and the secretion of IL-1/IL-18, which are key mediators of tubulointerstitial injury (107)

[DOI] [PubMed] [Google Scholar] 44.Refsvik T., Norseth T

It is also obtained through dietary sources, primarily meat and fish
Y.AiyerA.KabarritiR.KinkhabwalaM.et al (2019b)

Plasma nitrate and nitrite are increased by a high-nitrate supplement but not by high-nitrate foods in older adults

For chronic conditions, expect 8-12 weeks minimum
