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Pre-existing organ disease is widely treated as a hard contraindication

doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois

The rare if serious congenital diseases linked to TGF- and other cytokines in this family (Table 2) substantiate this point

Patients considering these injections should understand that B12 shots address a specific medical deficiency, whereas lipo shots are offered as complementary interventions without robust clinical evidence supporting their efficacy for weight loss or metabolic enhancement

At the biochemical level, GHK-Cu is understood to exert its effects through two converging mechanisms: direct modulation of copper-dependent enzymatic activity and transcription factor activation

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