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The antioxidant activity of melanoidins isolated from different brews was studied, and some showed that the radical scavenging ability of coffee melanoidins was higher in the dark-roasted coffee, others exhibited higher radical scavenging activity, and still others showed radical scavenging ability of coffee melanoidins was not affected by the degree of roasting (Tagliazucchi, 2010)

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Yes, oral vitamin B12 supplements can irritate the stomach in some individuals, causing gastrointestinal side effects including mild transient diarrhea