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This negative feedback contributes to the episodic and physiological nature of hormone release promoted by sermorelin, further distinguishing it from the continuous exposure caused by exogenous rhGH injections

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At 24 h, the upregulation of HMOX1 and GADD45B remained significant in both cell types, but DNAJB1 regulation declined and was no longer significant in HepG2 ATP7B-KO cells

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