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EBioMedicine 100 , 104952 (2024)

Box 616, 6200 MD Maastricht, Netherlands e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

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The majority of plant drugs reviewed presently in cisplatin-induced nephrotoxicity were found to be rich in flavones and flavonoids including Andrographis paniculata [59] , Aerva lanata , Biophytum sensitivum [60], Boerhaavia diffusa [61], Rhododendron dauricum [62], Phyllostachs pubescens [63], Gentiana patrinia [62], Pueraria tuberosa [64], Brassica oleracea [65], Foeniculum vulgare [66], Senna auriculata [67], and Cassia garretiana [68]

Interleukin-1 inhibits leydig cell steroidogenesis primarily by decreasing 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 expression