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Furthermore, results from a phase II clinical trial conducted on AD patients demonstrated that NR administration was associated with favorable alterations in cerebrospinal fluid biomarkers indicative of improved mitochondrial function [23]

Furthermore, unlike in experiments using animals, clinical studies usually involve patients with heterogeneous backgrounds, different ages, sexes, and sensitivity to stress

doi: 10.1136/annrheumdis-2014-eular.4476 34

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The analysis was also performed for Caucasian population alone which represented 67.2% of the study population