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Pernigoni et al (15) demonstrated, through metagenomic sequencing, a marked enrichment of bacterial strains (for example, certain Ruminococcaceae species) capable of encoding enzymes involved in androgen biosynthesis, such as androstenedione, in the fecal microbiota of men with CRPC

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Figure 5 6 Sleep disorders in cirrhosis 6.1 Prevalence, characteristics, and mechanisms Sleep disturbances worsen quality of life in cirrhosis, demanding vigilant management to uplift health-related quality of life (HRQoL) and clinical outcomes

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