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In order to generate a large sample population and exclude any possible bias, like the Hawthorne study shows, this retrospective study design was chosen to resemble daily clinical practice routines 51

Beyond lysosomal deacidification and inhibition of autophagosome-lysosome fusion, CQ/HCQ disrupts endolysosomal function, Toll-like receptor activation, and calcium signaling, thereby reducing pro-inflammatory cytokine production

& Ljungman, M

& Tackett, A

In an evolutionary distinction, mammalian cells typically operate unidirectionally, i.e., they can convert homocysteine to cysteine, but not the other way round (Finkelstein, 1990)