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Clinically, strategies aimed at modulating EAAC1-mediated cysteine transport and boosting endogenous GSH synthesis may hold promise for mitigating post-ischemic neurodegeneration and cognitive deficits associated with vascular dementia

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Nrf2 stabilization achieved maximal nuclear localization at 30 min that returned to basal levels at 900 min (15 h) (2-way ANOVA for interaction F(4,41) = 6, p = 0.0006)

E.Flores-AlfaroE.et al (2019)

In fact, coffee is the biggest single source of antioxidants in most peoples diets

However, there is no detailed information on the bio-mechanisms linking such clinical differences